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Before a suspicious lesion is removed, the doctor often takes a biopsy: a small sample of the lesion, or some fluid from it, so pathology can say whether it is benign or cancerous. A biopsy is a diagnostic procedure, not a treatment. The lesion stays; only a sample comes out.
There are three ways to take that sample: fine needle aspiration (FNA), core needle biopsy, and surgical biopsy (cutting the sample out, like the skin biopsies in Skin Biopsies, Paring & Skin Tags). This lesson covers the two needle techniques, because they're coded very differently.
Part 1 of 4
Two needle techniques
Picture it · two needle techniques
Fine needle aspiration (FNA)
1002110004–10012
Core needle biopsy
470005020020206…
| Fine needle aspiration (FNA) | Core needle biopsy | |
|---|---|---|
| What comes out | Fluid and loose cells | A solid strip (core) of tissue |
| Sent to | Cytology | Pathology |
| Where the codes are | Integumentary section, General codes (10004–10012, 10021) | The organ's own section |
| Imaging guidance | Built into the FNA code | Usually reported separately (7xxxx) |
| Needle size | Fine or larger gauge | Fine or larger gauge cutting needle |
Core biopsy codes live with the organ
There's no single "core biopsy" code. You look in the section for the organ that was sampled, for example:
| Organ | Percutaneous core / needle biopsy | Section |
|---|---|---|
| Muscle | 20206 | Musculoskeletal (20000s) |
| Bone, superficial / deep | 20220 / 20225 | Musculoskeletal (20000s) |
| Pleura | 32400 | Respiratory (30000s) |
| Lung or mediastinum | 32408 (includes imaging) | Respiratory (30000s) |
| Bone marrow, biopsy / biopsy and aspiration | 38221 / 38222 | Hemic and lymphatic (30000s) |
| Lymph node, superficial (cervical, inguinal, axillary) | 38505 | Hemic and lymphatic (30000s) |
| Liver | 47000 | Digestive (40000s) |
| Pancreas | 48102 | Digestive (40000s) |
| Abdominal or retroperitoneal mass | 49180 | Digestive (40000s) |
| Kidney | 50200 | Urinary (50000s) |
| Prostate | 55700 | Male genital (50000s) |
| Thyroid | 60100 | Endocrine (60000s) |
Older books list 32405 for a lung or mediastinum needle biopsy. It was deleted in 2024 and replaced by 32408, which includes the imaging guidance.
When the doctor uses imaging to place the core needle, add the guidance code from Radiology. These codes go with the core biopsy, never with an FNA:
| Guidance for core needle placement | Code |
|---|---|
| Ultrasound | 76942 |
| Fluoroscopy | +77002 (add-on) |
| CT | 77012 |
| MR | 77021 |
Part 2 of 4
One pair of codes for each kind of imaging
FNA codes are built around the imaging guidance. Each imaging type has two codes: one for the first lesion and an add-on for each additional lesion.
Picture it · one pair of FNA codes per imaging type
| Imaging guidance | FNA, first lesion | FNA, each additional lesion |
|---|---|---|
| No imaging | 10021 | +10004 |
| Ultrasound | 10005 | +10006 |
| Fluoroscopy | 10007 | +10008 |
| CT | 10009 | +10010 |
| MR | 10011 | +10012 |
- FNA with no imaging (the doctor feels the lump): 10021, then +10004 for each additional lesion.
- FNA with ultrasound: 10005, then +10006.
- FNA with fluoroscopy: 10007, then +10008.
- FNA with CT: 10009, then +10010.
- FNA with MR: 10011, then +10012.
Because the guidance is part of the FNA code, never add 76942, 77002, 77012 or 77021 for the FNA itself. Those separate guidance codes belong to the core biopsy (see the table in the first part).
Part 3 of 4
The five scenarios
The doctor can use both techniques in one session: both on the same lesion, or FNA on one lesion and a core biopsy on another. The CPT guidelines before the FNA codes explain how to report each combination. The deciding question is same lesion or different lesions.
Picture it · FNA and core biopsy in the same session
1Two lesions, FNA with ultrasound on both
- 1Right breast, upper lumpFNA · ultrasound
- 2Right breast, lower lumpFNA · ultrasound
Two separate lumps in the right breast are each aspirated under ultrasound.
10005+10006
Same imaging on both: the first-lesion code, then its own add-on.
2Two lesions, FNA with ultrasound, then FNA with fluoroscopy
- 1Neck lymph nodeFNA · ultrasound
- 2Left lung noduleFNA · fluoroscopy
An enlarged neck lymph node is aspirated under ultrasound, then a lung nodule under fluoroscopy.
1000510007
Different imaging: each lesion gets the first-lesion code for its own imaging type. +10008 can't go with 10005.
3One lesion, FNA and core biopsy, both with ultrasound
- 1Thyroid noduleFNA · ultrasoundCore biopsy · ultrasound
Under ultrasound, a thyroid nodule is aspirated for cells, then a core sample is taken from the same nodule.
1000560100
Same lesion, same imaging: report only the FNA code and the core biopsy code. No 7xxxx guidance code: the one ultrasound is already in 10005.
4Lesion 1 FNA with ultrasound, lesion 2 core biopsy with ultrasound
- 1Right axillary lymph nodeFNA · ultrasound
- 2Liver massCore biopsy · ultrasound
A right armpit lymph node is aspirated under ultrasound; then a liver mass has a core biopsy, also under ultrasound.
100054700076942-59/XS
Different lesions: the liver biopsy's ultrasound is its own service, coded with 59 or XS.
5Lesion 1 FNA with ultrasound, lesion 2 core biopsy with fluoroscopy
- 1Left breast lumpFNA · ultrasound
- 2Right ilium (hip bone)Core biopsy · fluoroscopy
A left breast lump is aspirated under ultrasound; then a lesion in the hip bone (ilium) has a needle biopsy under fluoroscopy.
1000520220+77002-59/XS
Different lesions, different imaging: the fluoroscopy is coded, with 59 or XS. The ilium is a superficial bone (20220).
- Two lesions, FNA with ultrasound on both. Two lumps in the right breast, each aspirated under ultrasound: 10005 + 10006. One imaging type, so the first lesion gets the primary code and the second gets its own add-on.
- Two lesions, FNA with ultrasound, then FNA with fluoroscopy. A neck lymph node by ultrasound and a lung nodule by fluoroscopy: 10005 + 10007. The imaging differs, so each lesion gets the first-lesion code for its own imaging type.
- One lesion, FNA and core biopsy, both with ultrasound. The doctor aspirates a thyroid nodule, then takes a core from the same nodule: 10005 + 60100. No 76942: there was one ultrasound on one lesion, and it's already paid inside 10005.
- Lesion 1 FNA with ultrasound, lesion 2 core biopsy with ultrasound. A right armpit lymph node is aspirated, then a liver mass has a core biopsy: 10005 + 47000 + 76942-59. The liver's ultrasound was for a different lesion, so it's reported, with 59 (or XS, separate structure, for Medicare).
- Lesion 1 FNA with ultrasound, lesion 2 core biopsy with fluoroscopy. A left breast lump by ultrasound, then a hip bone (ilium) biopsy by fluoroscopy: 10005 + 20220 + 77002-59. The ilium is a superficial bone (20220; a deep bone such as the femur is 20225), and +77002 is an add-on, again with 59 or XS.
Three and four lesions
The same rules stretch to any number of lesions. Go lesion by lesion:
- FNA: one pair per imaging type. The first lesion with that imaging gets the first-lesion code, every later one gets that pair's add-on.
- Core biopsy: one organ code per lesion. A second core of the same organ repeats the code with 59 or XS.
- Core guidance: each guidance code once for the session, with 59 or XS because an FNA was also done.
Picture it · three and four lesions in one session
1Three lesions: FNA ultrasound, FNA fluoroscopy, FNA fluoroscopy
- 1Thyroid noduleFNA · ultrasound
- 2Right lung noduleFNA · fluoroscopy
- 3Left lung noduleFNA · fluoroscopy
A thyroid nodule is aspirated under ultrasound, then two lung nodules under fluoroscopy.
1000510007+10008
Ultrasound once: 10005. The first fluoroscopy lesion starts its own pair (10007), and the second takes that pair's add-on (+10008).
2Four lesions: two by ultrasound, two by fluoroscopy
- 1Neck lymph nodeFNA · ultrasound
- 2Right axillary lymph nodeFNA · ultrasound
- 3Right ilium (hip bone)FNA · fluoroscopy
- 4Left ilium (hip bone)FNA · fluoroscopy
Two lymph nodes (neck, right armpit) are aspirated under ultrasound, then a lesion in each hip bone under fluoroscopy.
10005+1000610007+10008
Two imaging types, so two pairs: 10005 with its add-on +10006, and 10007 with its add-on +10008.
3Four lesions, FNA with fluoroscopy on all four
- 1Right upper lungFNA · fluoroscopy
- 2Left upper lungFNA · fluoroscopy
- 3Right lower lungFNA · fluoroscopy
- 4Left lower lungFNA · fluoroscopy
Four lung nodules, two in each lung, are each aspirated under fluoroscopy.
10007+10008+10008-59/XS+10008-59/XS
One first-lesion code, then +10008 for each of the other three lesions. When the same add-on repeats on separate lines, 59 or XS on the repeats shows each is a separate lesion.
4Three lesions: FNA ultrasound, then two liver cores by ultrasound
- 1Right axillary lymph nodeFNA · ultrasound
- 2Liver mass ACore biopsy · ultrasound
- 3Liver mass BCore biopsy · ultrasound
A right armpit lymph node is aspirated under ultrasound; then two separate liver masses each have a core biopsy under ultrasound.
100054700047000-59/XS76942-59/XS
Each liver mass is its own 47000, the second with 59 or XS. The cores share one ultrasound, so 76942 is reported once, with 59 or XS.
5Three lesions: FNA ultrasound, core by ultrasound, core by fluoroscopy
- 1Right axillary lymph nodeFNA · ultrasound
- 2Liver mass ACore biopsy · ultrasound
- 3Liver mass BCore biopsy · fluoroscopy
A right armpit lymph node is aspirated under ultrasound; one liver mass has a core biopsy under ultrasound and another under fluoroscopy.
100054700047000-59/XS76942-59/XS+77002-59/XS
Two cores: 47000, and 47000 with 59 or XS. Each core used a different imaging type, so both guidance codes are reported, each with 59 or XS.
- FNA ultrasound, FNA fluoroscopy, FNA fluoroscopy: 10005 + 10007 + 10008. Ultrasound has one lesion, so just 10005. Fluoroscopy has two, so 10007 then its add-on +10008.
- FNA ultrasound × 2, FNA fluoroscopy × 2: 10005 + 10006 + 10007 + 10008. Two pairs, one per imaging type.
- FNA fluoroscopy on four lesions: 10007 + 10008 + 10008-59 + 10008-59 (or XS). Each lesion after the first gets +10008; the repeated lines carry 59 or XS to show they're separate lesions.
- FNA ultrasound, then two liver cores by ultrasound: 10005 + 47000 + 47000-59 + 76942-59 (or XS). Two liver lesions, two 47000s. Both cores used ultrasound, so 76942 is reported only once.
- FNA ultrasound, liver core by ultrasound, liver core by fluoroscopy: 10005 + 47000 + 47000-59 + 76942-59 + 77002-59 (or XS). Each core used a different imaging type, so both guidance codes are reported.
Part 4 of 4
Practice cases
Case 1 · FNAThyroid nodule, palpation onlyOpen caseClose
A palpable thyroid nodule is aspirated with a 25-gauge needle. No imaging is used. Fluid is sent for cytology.
Your turn: code this case
Case 2 · FNATwo breast lesions, both under ultrasoundOpen caseClose
Under ultrasound guidance, FNA is performed on two separate breast lesions.
Your turn: code this case
Case 3 · FNANeck node by ultrasound, lung lesion by CTOpen caseClose
FNA of a cervical lymph node under ultrasound guidance, then FNA of a lung lesion under CT guidance, in the same session.
Your turn: code this case
Case 4 · FNA + coreSame liver lesion, FNA and core, both by ultrasoundOpen caseClose
Under ultrasound guidance, a single liver lesion is aspirated with a fine needle, and a core needle biopsy is taken from the same lesion.
Your turn: code this case
Case 5 · FNA + coreDifferent lesions, both by ultrasoundOpen caseClose
Ultrasound-guided FNA of a thyroid nodule, and in the same session an ultrasound-guided percutaneous core biopsy of a kidney mass.
Your turn: code this case
Case 6 · FNA + coreDifferent lesions, different imagingOpen caseClose
Ultrasound-guided FNA of an axillary lymph node, then a fluoroscopy-guided needle biopsy of a deep bone lesion in the same session.
Your turn: code this case
Case 7 · FNA, three lesionsOne ultrasound lesion, two fluoroscopy lesionsOpen caseClose
Same session: FNA of a thyroid nodule under ultrasound, then FNA of two separate lung nodules under fluoroscopy.
Your turn: code this case
Case 8 · FNA + two coresFNA of a node, two liver cores by ultrasoundOpen caseClose
Ultrasound-guided FNA of an axillary lymph node, then ultrasound-guided core biopsies of two separate liver masses, all in the same session.
Your turn: code this case
End of the chapter: check what you remember
- Biopsy is a diagnostic test: FNA draws fluid for cytology, a core needle takes tissue for pathology
- FNA codes come in pairs by imaging type: a first-lesion code and its own add-on
- Core biopsy codes sit with each organ, and imaging guidance is usually coded separately
- Same lesion and same imaging: no separate guidance code. Different lesions: guidance code with 59 or XS
